Stem Cells Grown in Space Could Revolutionize Medicine Here on Earth

The International Space Station (ISS) in orbit. Credit: NASA

Extended periods spent in microgravity can take a serious toll on the human body, leading to muscular atrophy, bone density loss, vision problems, and changes to the cardiovascular, endocrine, and nervous systems. At the same time, however, scientists have found that microgravity may play a key role in the future of medicine. This includes bioprinting in space, where cultured cells are printed out to form organic tissues and organs without the need for grafts. Printing in microgravity also ensures that fragile cell structures do not collapse due to pressures caused by Earth’s gravity.

However, space medicine may also have applications for stem cell research, which also benefit from a microgravity environment. Stem cells have countless applications in medicine because of their ability to quickly replicate and differentiate into many different types of cells. Based on experiments carried out aboard the International Space Station (ISS), researchers from the Mayo Clinic in Florida determined that these abilities are enhanced when grown in space. These findings could have significant benefits in the study of disease prevention and treatment on Earth, as well as medical treatments delivered in space.

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Space Travel Weakens the Heart, New Study Finds

The International Space Station (ISS) in orbit. Credit: NASA

It’s no secret that spending extended periods in space takes a toll on the human body. For years, NASA and other space agencies have been researching the effects of microgravity on humans, animals, and plants aboard the International Space Station (ISS). So far, the research has shown that being in space for long periods leads to muscle atrophy, bone density loss, changes in vision, gene expression, and psychological issues. Knowing these effects and how to mitigate them is essential given our future space exploration goals, which include long-duration missions to the Moon, Mars, and beyond.

However, according to a recent experiment led by researchers at Johns Hopkins University and supported by NASA’s Johnson Space Center, it appears that heart tissues “really don’t fare well in space” either. The experiment consisted of 48 samples of human bioengineered heart tissue being sent to the ISS for 30 days. As they indicate in their paper, the experiment demonstrates that exposure to microgravity weakens heart tissue and weakens its ability to maintain rhythmic beats. These results indicate that additional measures must be taken to ensure humans can maintain their cardiovascular health in space.

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Space Stations Get Pretty Moldy. How Can We Prevent it?

Ask any property inspector, and they’ll tell you one of the maxims of their profession – where there’s moisture, there’s mold. That relationship also holds true for the International Space Station. The interior climate on the ISS is carefully controlled, but if thrown out of whack, potentially dangerous mold could sprout overnight. A new paper by researchers at The Ohio State University explains why – and provides some insights into how we might prevent it if it does happen.

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Starliner Comes Home Empty

Boeing’s Starliner touches down at White Sands Space Harbor in New Mexico at 12:01 a.m. EDT Saturday, Sept. 7, completing the agency’s Crew Flight Test. Photo credit: NASA

The Boeing Starliner module has been plagued with issues despite what seemed to be the dawning of a new commercial space giant. The module detached from the International Space Station on 7 September but without its crew! Butch Wilmore and Suni Williams journeyed to the ISS in June this year in what was supposed to be a mission lasting just a week. They are still there! Just a few days ago, their module returned under remote control while they stay in orbit until February! 

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Astronauts’ Muscle Loss Mimics Age-Related Muscle Loss

Researchers grew muscle cells on tiny chips then sent them to the ISS to study them. Researchers hope to develop drugs to help astronauts combat muscle atrophy during space flight. Image Credit: NASA. CC BY-SA

One of the hazards astronauts must contend with is muscle loss. The more time they spend in a microgravity environment, the more muscle loss they suffer. Astronauts use exercise to counter the effects of muscle atrophy, but it’s not a perfect solution. Researchers want to develop drugs to help, and understanding the muscle-loss process in space is a critical first step.

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Crew-8 Arrives at the ISS, Despite a Crack in the Capsule

Launch of Crew 8

Space travel seems to be a fairly regular occurrence now with crews hopping up and down to the International Space Station. This week, another crew arrived on board a SpaceX Dragon capsule known as Endeavour.  On board were NASA astronauts Matthew Dominick, Michael Barratt and Jeanette Epps along with cosmonaut Alexander Grebenkin. The ISS already had seven people on board so this brought the total crew to eleven. The launch almost got cancelled due to a crack in the hatch seal. 

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The International Space Station’s Air Leaks are Increasing. No Danger to the Crew

International Space Station. Credit: NASA

Only the other week I had to fix my leaky tap. That was a nightmare.  I cannot begin to imagine how you deal with a leaky spacecraft! In August 2020 Russia announced that their Zvezda module had an air leak. An attempt was make to fix it but in November 2021 another leak was found. Earlier this week, Russia announced the segment is continuing to leak but the crew are in no danger. 

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Can We Survive in Space? It Might Depend on How Our Gut Microbiome Adapts

Researchers at Penn State University are developing a way to use microbes to turn human waste into food on long space voyages. Image: Yuri Gorby, Rensselaer Polytechnic Institute
Microbes play a critical role on Earth. Understanding how they react to space travel is crucial to ensuring astronaut health. Credit: Yuri Gorby, Rensselaer Polytechnic Institute

For over a century, people have dreamed of the day when humanity (as a species) would venture into space. In recent decades, that dream has moved much closer to realization, thanks to the rise of the commercial space industry (NewSpace), renewed interest in space exploration, and long-term plans to establish habitats in Low Earth Orbit (LEO), on the lunar surface, and Mars. Based on the progression, it is clear that going to space exploration will not be reserved for astronauts and government space agencies for much longer.

But before the “Great Migration” can begin, there are a lot of questions that need to be addressed. Namely, how will prolonged exposure to microgravity and space radiation affect human health? These include the well-studied aspects of muscle and bone density loss and how time in space can impact our organ function and cardiovascular and psychological health. In a recent study, an international team of scientists considered an often-overlooked aspect of human health: our microbiome. In short, how will time in space affect our gut bacteria, which is crucial to our well-being?

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The International Space Station Celebrates 25 Years in Space

25 years of ISS
25 years of ISS

NASA recently celebrated the 25th anniversary of the International Space Station (ISS) with a space-to-Earth call between the 7-person Expedition 70 crew and outgoing NASA Associate Administrator, Bob Cabana, and ISS Program Manager, Joel Montalbano. On December 6, 1998, the U.S.-built Unity module and the Russian-built Zarya module were mated in the Space Shuttle Endeavour cargo bay, as Endeavour was responsible for launching Unity into orbit that same day, with Zarya having waited in orbit after being launched on November 20 from Kazakhstan.

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We Don't Know Enough About the Biomedical Challenges of Deep Space Exploration

Artist's impression of astronauts on the lunar surface, as part of the Artemis Program. Credit: NASA
Artist's impression of astronauts on the lunar surface, as part of the Artemis Program. Credit: NASA

Although humans have flown to space for decades, the missions have primarily been in low-Earth orbit, with just a handful of journeys to the Moon. Future missions with the upcoming Artemis program aim to have humans living and working on the Moon, with the hopes of one day sending humans to Mars.

However, the environments of the Moon and deep space present additional health challenges to astronauts over low-Earth orbit (LEO), such as higher radiation, long-term exposure to reduced gravity and additional acceleration and deceleration forces. A new paper looks at the future of biomedicine in space, with a sobering takeaway: We currently don’t know enough about the biomedical challenges of exploring deep space to have an adequate plan to ensure astronaut health and safety for the Artemis program.

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