Manned missions to deep space present numerous challenges. In addition to the sheer amount of food, water and air necessary to keep a crew alive for months (or years) at a time, there’s also the question of keeping them busy for the entirety of a long-duration flight. Exercise is certainly an option, but the necessary equipment will take up space and be a drain on power.
In addition, they’ll need room to move around, places to sleep, eat, work, and relax during their down time. Otherwise, they will be at risk of succumbing to feelings of claustrophobia, anxiety, insomnia, and depression – among other things.