The Shelf Life of Many Medications Is Shorter Than A Round Trip To Mars

Color mosaic image of Mars, taken by the HRSC instrument aboard the ESA's Mars Express orbiter. Credit: ESA/DLR/FU Berlin (G. Michael)

Check any container of over-the-counter medicine, and you’ll see its expiration date. Prescription medicines have similar lifetimes, and we’re told to discard old medications rather than hold on to them. Most of them lose their effectiveness over time, and some can even become toxic. We’re discouraged from disposing of them in our wastewater because they can find their way into other organisms, sometimes with deleterious effects.

We can replace them relatively easily on Earth, but not on a space mission beyond Low Earth Orbit.

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Will Space Tourists Be Getting Heart Attacks in Space?

Crew Dragon docking with ISS

Astronauts are considered by many to be an elite bunch of people; healthy, fit and capable in many disciplines. Went they travel into space they can face health issues related to weightlessness from reduction in bone density to issues with their eyesight. These are people at the peak of physical fitness but what will happen to the rest of us when space tourism really kicks off. It is likely that anyone with underlying health issues could worsen in space. A new study suggests those with cardiovascular issues may suffer heart failure in space!

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Lunar Explorers Could Run to Create Artificial Gravity for Themselves

A close-up view of astronaut Buzz Aldrin's bootprint in the lunar soil, photographed with the 70mm lunar surface camera during Apollo 11's sojourn on the moon. There'll soon be more boots on the lunar ground, and the astronauts wearing those boots need a way to manage the Moon's low gravity and its health effects. Image by NASA

Few things in life are certain. But it seems highly probable that people will explore the lunar surface over the next decade or so, staying there for weeks, perhaps months, at a time. That fact bumps up against something we are certain about. When human beings spend time in low-gravity environments, it takes a toll on their bodies.

What can be done?

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Electrodes in Spacesuits Could Protect Astronauts from Harmful Dust on Mars

Martian dust could be a serious health hazard for future missions to Mars. Credit: NASA/AI. SpaceFactory

To quote NASA associate administrator Jim Reuter, sending crewed missions to Mars by 2040 is an “audacious goal.” The challenges include the distance involved, which can take up to six months to traverse using conventional propulsion methods. Then there’s the hazard posed by radiation, which includes increased exposure to solar particles, flares, and galactic cosmic rays (GCRs). And then there’s the time the crews will spend in microgravity during transits, which can take a serious toll on human health, physiology, and psychology.

But what about the challenges of living and working on Mars for several months at a time? While elevated radiation and lower gravity are a concern, so is Martian regolith. Like lunar regolith, dust on Mars will adhere to astronauts’ spacesuits and inflict wear on their equipment. However, it also contains harmful particles that must be removed to prevent contaminating habitats. In a recent study, a team of aerospace engineers tested a new electrostatic system for removing Martian regolith from spacesuits that could potentially remove harmful dust with up to 98% efficiency.

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Can We Survive in Space? It Might Depend on How Our Gut Microbiome Adapts

Researchers at Penn State University are developing a way to use microbes to turn human waste into food on long space voyages. Image: Yuri Gorby, Rensselaer Polytechnic Institute
Microbes play a critical role on Earth. Understanding how they react to space travel is crucial to ensuring astronaut health. Credit: Yuri Gorby, Rensselaer Polytechnic Institute

For over a century, people have dreamed of the day when humanity (as a species) would venture into space. In recent decades, that dream has moved much closer to realization, thanks to the rise of the commercial space industry (NewSpace), renewed interest in space exploration, and long-term plans to establish habitats in Low Earth Orbit (LEO), on the lunar surface, and Mars. Based on the progression, it is clear that going to space exploration will not be reserved for astronauts and government space agencies for much longer.

But before the “Great Migration” can begin, there are a lot of questions that need to be addressed. Namely, how will prolonged exposure to microgravity and space radiation affect human health? These include the well-studied aspects of muscle and bone density loss and how time in space can impact our organ function and cardiovascular and psychological health. In a recent study, an international team of scientists considered an often-overlooked aspect of human health: our microbiome. In short, how will time in space affect our gut bacteria, which is crucial to our well-being?

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What Can Be Done to Help Astronaut Vision in Space?

Astronauts Kate Rubins (left) and Jeff Williams (right) looking out of the ISS' cupola at a SpaceX Dragon supply spacecraft. Until recently, the effects of long-duration missions on eyesight was something of a mystery. Credit: NASA

Spaceflight takes a serious toll on the human body. As NASA’s Twin Study demonstrates, long-duration stays in space lead to muscle and bone density loss. There are also notable effects on the cardiovascular, central nervous, and endocrine systems, as well as changes in gene expression and cognitive function. There’s also visual impairment, known as Spaceflight-Associated Neuro-ocular Syndrome (SANS), which many astronauts reported after spending two months aboard the International Space Station (ISS). This results from increased intracranial pressure that places stress on the optic nerve and leads to temporary blindness.

Researchers are looking for ways to diagnose and treat these issues to prepare for future missions that will involve long-duration stays beyond Earth and transits in deep space. A cross-disciplinary team of researchers led by the University of Western Australia (UWA) has developed a breakthrough method for measuring brain fluid pressure that could reduce the risk of SANS for astronauts on long-duration spaceflights. This research could have applications for the many efforts to create a human presence on the Moon in this decade and crewed missions to Mars in the next.

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Study Shows How Cells Could Help Artemis Astronauts Exercise

NASA’s Orion spacecraft will carry astronauts further into space than ever before using a module based on Europe’s Automated Transfer Vehicles (ATV). Credit: NASA

In 2033, NASA and China plan to send the first crewed missions to Mars. These missions will launch every two years when Earth and Mars are at the closest points in their orbits (Mars Opposition). It will take these missions six to nine months to reach the Red Planet using conventional technology. This means that astronauts could spend up to a year and a half in microgravity, followed by months of surface operations in Martian gravity (roughly 40% of Earth gravity). This could have drastic consequences for astronaut health, including muscle atrophy, bone density loss, and psychological effects.

Aboard the International Space Station (ISS), astronauts maintain a strict exercise regimen to mitigate these effects. However, astronauts will not have the same option while in transit to Mars since their vehicles (the Orion spacecraft) have significantly less volume. To address this challenge, Professor Marni Boppart and her colleagues at the Beckman Institute for Advanced Science and Technology are developing a process using regenerative cells. This work could help ensure that astronauts arrive at Mars healthy, hearty, and ready to explore!

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The International Space Station Gets a Clean Bill of Health. Despite a Few Opportunistic Microbes, the Station is “Safe” for Astronauts

In a recent study published in Microbiome, a team of researchers led by NASA’s Jet Propulsion Laboratory conducted a five-year first-of-its-kind study investigating the microbiome (environmental profile) of the International Space Station (ISS). The purpose of the study was to address “the introduction and proliferation of potentially harmful microorganisms into the microbial communities of piloted spaceflight and how this could affect human health”, according to the paper.

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Want to Stay Healthy in Space? Then you Want Artificial Gravity

A close up of three fruit flies, used for scientific research both on Earth and in space. Credits: NASA Ames Research Center/Dominic Hart

Space travel presents numerous challenges, not the least of which have to do with astronaut health and safety. And the farther these missions venture from Earth, the more significant they become. Beyond Earth’s protective atmosphere and magnetosphere, there’s the threat of long-term exposure to solar and cosmic radiation. But whereas radiation exposure can be mitigated with proper shielding, there are few strategies available for dealing with the other major hazard: long-term exposure to microgravity.

Aboard the International Space Station (ISS), astronauts rely on a strict regimen of exercise and resistance training to mitigate the physiological effects. These include muscle atrophy, bone density loss, organ function, eyesight, and effects on cardiovascular health, gene expression, and the central nervous system. But as a recent NASA study revealed, long-duration missions to Mars and other locations in deep space will need to be equipped with artificial gravity. This study examined the effects of microgravity on fruit flies aboard the ISS and demonstrated artificial gravity provides partial protection against those changes.

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Using Virtual/Augmented Reality and Holoportation to Help Improve Mental Health for Future Mars Astronauts

We recently explored how the Apple TV+ series, For All Mankind, gives us a harsh reality check about the harshness of human space exploration. In the show, astronauts struggle, some go crazy, and a lot of them die in the pursuit of planting our flag just a little farther from home. We discussed how while For All Mankind is both science fiction and takes place in an alternate universe, our future Artemis and Mars astronauts will very likely endure the same struggles and hardships as the show’s beloved characters.

When Artemis astronauts finally land on the Moon, they’ll be there anywhere from a few days to a few months. While the Moon is only a few days travel time from Earth, Artemis astronauts may still get a little cranky being stuck in their habitat and unable to go outside without a spacesuit.

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